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KMID : 1134820090380121712
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 12 p.1712 ~ p.1717
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Effect of Enteral Capsaicin on the Lymphatic Absorption of Cholesterol and Fats in Rats
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Seo Yun-Jung
Kim Ju-Yeoun
Noh Sang-Kyu
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Abstract
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Capsaicin has been shown to affect lipid metabolism. However, it is currently not known whether capsaicin would lower the intestinal absorption of cholesterol. Thus, this study was conducted to investigate the effect of intraduodenally infused capsaicin on the lymphatic absorption of cholesterol and lipids in rats. Male Sprague-Dawley rats weighing 300~350 g were starved for 16 hr and the mesenteric lymph duct was cannulated. Each rat was infused at 3.0 mL/hr for 8 hr via the duodenal catheter with a lipid emulsion, which contained 33.3 kBq [14C]-cholesterol, 20.7 μ㏖ cholesterol, 452 μ㏖ triolein, 3.1 μ㏖ α-tocopherol, and 396.0 μ㏖ Na-taurocholate without (control) or with 5.0 ㎎ capsaicin in 24 mL PBS buffer (pH 6.4). Simultaneously, lymph was collected hourly for 8 hr. There was no significant difference in lymph flow between the groups. However, the lymphatic absorption of 14C-cholesterol for 8 hr was significantly lower in rats infused with capsaicin than in those infused with no capsaicin. Also, the output of oleic acid for 8 hr was significantly decreased by capsaicin. However, the intestinal absorption of α-tocopherol did not differ between the groups. The results indicate that the luminal infusion of capsaicin inhibits the intestinal absorption of cholesterol and lipids in rats.
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KEYWORD
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capsaicin, cholesterol, intestine, absorption, lipid
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